Chronic liver disease is known as the silent killer, as it shows no obvious symptoms until the disease has progressed to an advanced stage. Therefore, making a proper diagnosis in the early stage of disease progression can be a clinical challenge. An international team of researchers, affiliated with Ulsan National Institute of Science and Technology (UNIST), has identified a novel route that regulates the signalling pathways induced by extracellular matrix (ECM). This may serve as a new diagnostic marker and therapeutic target in the fight against chronic liver diseases. The research has been supported by the Research-driven Hospitals Project through the Ministry of Health & Welfare, the Ministry of Science and ICT, and the Basic Science Research Program through the National Research Foundation.