FAQ

Any technology that utilizes the principles of biology is considered biotechnology.

To be more precise modern biotechnology provides breakthrough products and technologies to combat debilitating and rare diseases, reduce our environmental footprint, feed the hungry, use less and cleaner energy, and have safer, cleaner and more efficient industrial manufacturing processes. Biotechnology, often referred to as Biotech has existed since the beginning of civilization with the domestication of plants, animals and the discovery of fermentation. Humanity has been using the biological processes of microorganisms for more than 6,000 years to make useful food products, such as bread and cheese, and to preserve dairy products.

The biotechnological branch is the most prominent component of the life sciences. Simply put, that leverages our understanding of the natural sciences for many problems of our world. Biotechnology is a toolbox to create solutions for healthspan enhancement and longevity. The pharmaceutical industry is often considered a life science industry with its focus on the development, creation, and distribution of medications to aid the health of living things. Biotechnology or Biotech is a subset of each of these. The growing Biotech industry focuses on a few major areas including medical / healthcare, agricultural or food production and the environment through which living organisms are used or manipulated to create a useable product.

Biotechnology is a process that utilises enzymes and microorganisms to produce specific products through the use of fermentation under controlled conditions. Examples of products which are produced this way and are used within the beauty industry include hyaluronic acid and resveratrol. To obtain these compounds directly from plants would take a lot of water, energy, land and many processing steps to extract the desired compounds, this is impracticable and unsustainable.

Thanks to biotechnology, biotech cosmetics and skincare can protect endangered and over-consumed natural ingredients. Biotech cosmetics drastically limit environmental impact and as scientifically altered and tested ingredients, they often perform better on the skin. In cosmetics, these biotech processes are often carried out in a bioreactor. By utilizing biotechnology, the beauty industry is able to create products that are both safe for the environment and effective for consumers.

Better ingredients. Biotechnology has potential beyond creating alternatives to animal- and plant-derived ingredients. It will likely make many of the beauty industry's most requested products more effective, minus any environmental impact. Some beauty brands already started to utilise biotechnology to cultivate genetically modified plants that can create more sustainable ingredients. Beauty consumers are constantly searching for products that deliver on their marketing promises. But for all the advances beauty innovation is capable of from a formulation perspective, there are some limits to what is possible by cosmetic chemists in a lab.

For example, Revela, a hair loss and skincare brand that utilizes biotechnology to develop new molecules for their product formulas. There are billions of ingredients out there that could potentially benefit ones hair or skin  whatever problem you're trying to solve. The challenge is how to find the right fit. The company applied the bioengineering and advanced AI techniques that were initially used for cancer research to develop the brand's patented ingredients: Procelinyl, which stimulates dormant hair follicles to combat hair loss, and Fibroquin, which promotes an active collagen pathway so skin remains toned throughout the aging process. While there are established ingredients that can deliver similar hair growth and collagen-producing benefits—such as Minoxidil (the active ingredient in Rogaine) and retinol— there is something to be said for beauty breakthroughs that are made possible with advanced biotechnology. AI is good at finding patterns between specific ingredients and what you're looking for. Every ingredient is like a puzzle piece; the AI is a puzzle solver. A human can maybe solve a 1000-piece puzzle, but for a computer, it becomes possible to find these patterns and this specific output you're looking for.

Better formulas. More effective ingredients mean consumers can feel more confident in their beauty purchases, and even better, they might pose less of a risk to your health. Unfortunately, beauty products with potentially harmful chemicals have spurred numerous recalls in recent years—one of the largest being Johnson & Johnson's 2021 aerosol SPF recall due to the presence of benzene in some products, a known carcinogen. Biotech offers a chance to formulate without using questionable ingredients. 

For example, Evolved by Nature, a biotech brand backed by Chanel that raised $120 million in series C funding in June 2022, has developed Activated Silk biotechnology, which will reportedly replace 560,000 metric tons of acrylic acid, a potential skin irritant used in hygiene products, and 1,056,000 metric tons of sodium laureth sulfate, a surfactant used in many personal care products. These ingredients are nearly unavoidable in some industry sectors, which is why investors and heritage beauty brands are taking notice of biotech's potential.

Read more by the link 

The importance of biotechnologies in sustainability is irreplaceable. Have you ever wondered how many palm trees need to be destroyed in order to extract palm oil? Or, for example, it takes roughly 200,000 rose petals to create a few millimeters of rose oil. That's where biotechnology comes into play. Biotechnology can help avoid the destruction and overuse of organic and animal-based sourcing as they are wholly unsustainable. It is impossible to meet the needs of humanity in natural ways. The truth is that Earth could not simply grow enough plants to sustain the beauty industry. It requires a huge amount of unrenewable resources that have a strict limit on planet Earth. That is why the beauty industry began to move away from this sourcing format to more plant-based alternatives. "Green" and "clean" beauty products with more plant-focused ingredients have seen a surge in popularity over the last few years. 

Developing comparable ingredients in a laboratory setting, rather than harvesting them from the Earth—which often requires massive amounts of water and land, among other biological resources—can help stave off the type of environmental catastrophe climate experts have warned us about for years. This is especially true in the case of palm oil, a widely used ingredient in the personal care industry that can be found in everything from surfactants (which creates a lather in soap and shampoos) to emulsifiers (which maintain the texture of certain lotions and creams). Harvesting palm oil, however, involves a wide range of issues. For example, the plant palm oil is derived from only grows within ten degrees of the equator.  Additionally, palm oil production (along with beef and soy) is responsible for over 60% of today's deforestation, and its agricultural supply chain is riddled with child and slave labor. This area around the equator is home to some of the most precious land on Earth—carbon-dense, biodiversity-rich tropical rainforest, and peatland. Preserving these carbon stores is essential for mitigating climate change, yet we've allowed palm oil producers to slash and burn these forests for decades, replacing them with industrial oil palm plantations.  Biotech drives massive breakthroughs in medicine, and recently it's spurred numerous innovations to support animal-free protein options. There's an opportunity to use precision fermentation to solve the massive problem of agricultural palm oil and to support the consumer products industry.

Biotech applies newly discovered methods and developed products helping to heal the world by harnessing nature's own toolbox and using our own genetic makeup to heal and guide lines of research by:

• Reducing rates of infectious disease;
• Saving millions of children's lives;
• Changing the odds of serious, life-threatening conditions affecting millions around the world;
• Tailoring treatments to individuals to minimize health risks and side effects;
• Creating more precise tools for disease detection;
• Combating serious illnesses and everyday threats confronting the developing world.

Longevity is defined as a "long life" or "a great duration of life." The duration of human life (longevity) is a complex trait, influenced by the classical three components such as genetics, the environment, and lifestyle. Several environmental and physiological factors contribute to the aging process. However, about 40% of human life expectancy is inherited among generations, and many lifespan-associated genes, genetic mechanisms and pathways have been demonstrated during the last decades.

Сoncern for longevity is becoming a big trend and more real, with great advances in science and the advent of new cutting-edge technologies. The person, in principle, can take care of himself, but correctly and professionally these personalised measures could be provided by specialists such as for example, physiotherapists, as well as doctors. They are able to make a complete inspection and analysis of the human body, prescribe the right supplements or medications (if necessary), plan a peronal healthy diet, proper physical activity, etc.

Precision medicine physicians provide routine and chronic care that relates to achieving health and wellness goals as well as focused primary and urgent care of human health. Those who properly and effectively and systematically take care of their lives are called longevists.  Physical traits and attributes can guide lifestyle decisions and prolong life. Trained in precision medicine, your personal physician will take care of your medical needs and optimize your health and longevity. Integration of all of your data including genetic, blood and imaging biomarkers in order to create a comprehensive action plan for your longevity and performance goals.

While longevity means how long one actually live past the average, lifespan defines how long one could potentially live. In its turn, healthspan is the period of life spent in good health free from chronic diseases and the disability of aging. It is not merely the absence of disease, but health is the state of complete physical, mental, and social well-being.

Longevitist is a person / individual who is professionally engaged in prolonging quality of life based on the latest technological discoveries and achievements of life science and the latest biotechs. Longevitists are mainly focused on biological immortality, which aims radically extend the healthy human lifespan.

Since the mid-20th century, medicine and improvements in nutrition and quality of life have lengthened life in old age. But while the number of supercentenarians—people over 110—has increased exponentially, the age they reach has not, suggesting that longevity has not been significantly extended.

Healthspan is a period of life spent in good health, free from the chronic diseases and disabilities of aging. Nobody wants just more years of life. People don't want to live 120 years with sicknesses, disabilities or loss of memories. Is not just about living longer, it's about living healthier longer.

Healthspan enhancement is a set of specific activities and initiatives of an individual (more often longevitists) aimed at improving the state of health, getting rid of chronic diseases and enhancing the quality of life, respectively, achieving health and longevity. This is achieved by conducting a personal inventory of the individual's health needs, such as regular individual exercise to improve physical fitness, exercise and wellness, proper diagnosis and administration of supplementation and medicaments, proper nutrition, private diet, as well as programs for the active rejection of bed habits resulting in a healthy lifestyle. Such systematic monitoring and implementation of certain activities results in improvements leading to greater well-being and happiness in people's personal lives, cognitive improvements etc. With the help of life science developments and discoveries and cutting-edge human enhancement biotechnologies, it becomes possible to radically enhance the length of human life.

In order to achieve healthsapn enhancement it is important to adhare the main lifestyle factors that will benefit your health. We should name such as: 

• A healthy balanced diet, a wise supplementation, vitaminization, medicamentation;
• Body hydration (regular water consumption);
• Regular Exercising;
• Plenty of sleep;
• Not smoking. Reducing alcohol consumption and avoiding other bad habits; 
• Keep a check on mental and physical health;
• Take regular tests to understand the presence or absence of certain substances in the body and its need;
• Track the health indicators to avoid chronic diseases;
• Constant tracking of the main health indicators such as heart rate, sugar level, pulse level, and others.

The increase in healthspan could primarily be achieved through personal health care based on personal diagnosis and personal vital signs, as well as proper nutrition, exercise and the prevention of hazards such as smoking, etc. The maximum lifespan is determined by the rate of aging of the species embedded in its genes and environmental factors. The potential of human life is great enough. According to conservative estimates, the idea of active longevity has been circulating in society for at least 120 years. We want to meet deep old age in good health. This is entirely possible by consistently applying a holistic approach to body and health through all of the above.

Life science is the study of living things, such as humans, plants, animals, and even microscopic organisms. Life science is one of two major branches in the sciences except for physical science (the sciences dealing with non-living matter). Life science is also called biological science. There are various branches of life science which are more human-related such as biology, biochemistry, neuroscience, etc. The other life sciences such as zoology, botany, and ecology are focused on various living organisms and continue to make new discoveries about the animals, and plants we share a planet with. As the field is so wide-reaching, there are plenty of degrees to choose from depending on the interests. The life sciences industry refers to all of the organizations and companies whose work is centered around research and development focused on living things (humans, animals, plants beings). It consists of companies operating in the fields of pharmaceuticals, biotechnology, medical devices, biomedical technologies, nutraceuticals, cosmeceuticals, food processing, and others that dedicate their efforts to creating products to improve the lives of organisms (not only humans). 

The life sciences industry comprises companies operating in the research development and manufacturing of pharmaceuticals, biotechnology-based food and medicines, medical devices, biomedical technologies, nutraceuticals, cosmeceuticals, food processing and other products that improve the lives of organisms. It is now over a decade since a growing number of life science specialist researchers and laboratories all around the world began to conceptualize and tackle human age-related diseases and enhance healthspan in a unified and comprehensive way utilizing all techs and discoveries in the various life science fields. Beyond lifestyle, nutritional, and environmental factors—areas in which we should seek continuous improvement, with due regard to their social and economic dimensions—there are other avenues that could be beneficial to explore. These include new medicinal substances, cellular, molecular, genetic, and epigenetic engineering, microbiota manipulation, human–machine hybridization, and nanotechnology.

Personalization in life science is characterized by an individual analysis conducted in order to define and determine the shortcomings that require improvement of the healthspan of a particular individual for longevity. Such a modern engineering approach to the human body is considered as a mechanism that consists of different systems, in which the functioning and the main indicators are constantly monitored and controlled, and based on the data and diagnosis, is performed support, adjustment and improvement of all systems, which results in early disease prevention, relief of chronic diseases, promoting health, combating aging and, accordingly, extending the lifespan. As a derivative of such a personalized approach to the body as a single system, the most effective enhancement of health results for longevity are achieved.

In personalised medicine, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient's genetic content or other molecular or cellular analysis. The use of genetic information has played a major role in certain aspects of personalized medicine (e.g. pharmacogenomics), and the term was first coined in the context of genetics, though it has since broadened to encompass all sorts of personalization measures including the use of proteomics, imaging analysis, nanoparticle-based theranostics, among others.

Precision medicine (PM) is a medical model that proposes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to a subgroup of patients, instead of a one‐drug‐fits‐all model. In precision medicine, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient’s genetic content or other molecular or cellular analysis. Tools employed in precision medicine can include molecular diagnostics, imaging, and analytics. Precision Medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It does not literally mean the creation of drugs or medical devices that are unique to a patient, but rather the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease, in the biology or prognosis of those diseases they may develop, or in their response to a specific treatment.

Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals. While there is no universally accepted definition, the EU Health Ministers in their Council conclusions on personalised medicine for patients, published in December 2015, defined personalised medicine as: A medical model using characterization of individuals’ phenotypes and genotypes (e.g. molecular profiling, medical imaging, lifestyle data) for tailoring the right therapeutic strategy for the right person at the right time, and/or to determine the predisposition to disease and/or to deliver timely and targeted prevention. 

Personalised Medicine should be seen as an evolution of medicine, and many challenges remain before its successful application across healthcare systems. New genetic technologies such as pharmacogenomics, often summarised under the term -'Omics' enable scientists to use patients' genetic information to better determine the right active substance, dose and time. The emergence of these technologies marks a step closer to personalised medicine. 

Personalized medicine is strongly focused on wellness and disease prevention. Testing can determine a person’s risk of developing medical conditions such as:

• Cancer;
• Diabetes;
• Cardiovascular disease;
• Addiction;
• Dementia;
• Parkinson’s disease;
• Alzheimer’s;
• Mood disorders.

Genomic testing also helps determine the best course of treatment for an already-developed disease, like cancer or HIV/AIDS. Knowledge of genetic mutations makes it possible for patients to have therapy that is far more targeted, accurate, and, therefore, effective. Diagnosis of a disease and the treatment applied to the disease do not always indicate success. Knowing a person’s potential reaction to a treatment can help a clinician determine if that medical intervention is the right one, or if it might do more harm than good. Adverse reactions to drugs could occur – but genomic information could have provided this information ahead of time. Trying out different treatments to find the “best” one is a waste of time, and it’s a horrible opportunity for disease to become more advanced.

It’s a complex question without definitive answers. However, more advances are being made here than ever before, from creating novel drug therapeutics to blood plasma transfusions. Here are some of the main tools human may utilize to slow down aging: 

• Pharmaceuticals. Drug therapies make up the vast portion of potential treatments in this area. Below, we highlight some of the prominent types of drugs that could help slow aging.
• Regenerative medicine. Regenerative medicine has been a big area of interest for restoring the structure and function of damaged tissues or organs. And this could be a crucial part of increasing longevity as individuals replace damaged body parts with new ones.
• Caloric restriction. There’s a recent wave of research looking at the role that caloric restrictions play in promoting longevity. This consists of reducing overall caloric intake with a carefully maintained diet to avoid malnutrition.
• Dietary supplements. Dietary supplements in the form of NAD+ (nicotinamide adenine dinucleotide) — or its precursors NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) — have become a focus in the longevity space. They are all forms of the vitamin B3 — also known as niacin — which has digestive, skin, and mental health benefits. In particular, NAD+ has been receiving a lot of attention recently. It is a naturally occurring key molecule known as a coenzyme that regulates healthy metabolism and other biological processes in the body. It exists in every cell in the body because it impacts everything from DNA repair to creating energy needed to conduct vital cellular processes. It plays an important role in facilitating key biochemical pathways that need to function properly in order to avoid disease. And it’s been shown that NAD+ levels start to fall with age.

The private company with ready-to-market physical products (in separate cases, at the latest stage of development and will be ready to market in the nearest future) based on the latest scientific technologies and discoveries developed by ultra-experienced and highly talented engineers who have previously worked for many years for global corporations accumulating significant knowledge, expertise and connections in their field and spun off to create their own brand.

Such brands outgrowth from the lab to wide adoption passing through such stages as scientific research, clinical trials, commercialization, and market diffusion. Once it is launched on the market, it is responsibly diffused to deliver beneficial healthspan impact at scale in various industries such as big and small pharma, medicine, nutrition, superfoods, wellness, beauty, medtech and more.

Superfoods are foods that have a high nutritional value and density because they cover a large part of our nutritional and energy needs. This means that they have the power to give you a substantial amount of nutrients with less calories. They have rare and unique ingredients that benefit to specific body functions, contributing to our health. Healthy eating is all about picking the right food. That means eat superfoods every day to get maximum nutrients. Everyone promotes a balanced diet, but having meals with all the nutrients is not possible. One food might be a rich source of fibre or protein but might be lacking in certain vitamins. Another one could be full of antioxidants, but again might not be a good source of certain minerals needed by our body. That’s why there are superfoods, which are beneficial for your body.

Morover, superfoods contain a high volume of minerals, vitamins and antioxidants — everything that your body needs.Antioxidants, which are natural molecules found in specific foods, help to neutralise free radicals in our bodies. Free radicals are natural byproducts of energy production that can harm our bodies. Antioxidant molecules decrease or reverse the effects of free radicals that have close links with health problems such as:

• Heart disease
• Cancer
• Arthritis
• Stroke
• Respiratory diseases
• Immune deficiency

Inflammation is a natural response of the immune system to injury, infection, or stress. However, when inflammation becomes chronic or widespread, it can contribute to the development of many chronic diseases, such as arthritis, diabetes, heart disease, and even cancer. The good news is that you can help reduce inflammation in your body by incorporating more anti-inflammatory foods into your diet. By incorporating more anti-inflammatory foods and supplementation into your diet, you can help reduce chronic inflammation in your body and promote optimal health and well-being.

The success of any weight loss diet depends on two things - a calorie deficit and appetite control. Cutting too much or drastically in the calorie intake will make you feel more hungry. Difficulties in controlling appetite may be faced by people who have made a moderate calorie deficit and have a balanced diet. This is because they are used to eating more food than they currently eat. There are several ways to control hunger during weight loss: pills, natural methods and a well-planned diet, but first things first.

More scientific breakthroughs enable more commercial applications. Biology research is continually developing, and scientific breakthroughs we haven’t yet contemplated could provide a foundation for downstream commercial applications that may become available in the next few decades. For example, before the Human Genome Project, researchers knew the genetic basis of tens of disorders. Today, they know the basis of thousands of conditions. Genomics is thus helping transform medicine. More than 100 different drugs approved by the US Food and Drug Administration (FDA) are now packaged with instructions that tell doctors to test their patients for genetic variants linked to efficacy, dosages, or risky side effects.31 Funding basic science or helping promising applications accelerate through research pipelines could directly influence the number of commercial applications in the future.

A confluence of advances in biological sciences—decades in the making—with the accelerating development of computing, automation, and artificial intelligence (AI), is fueling a new wave of innovation that could have significant impact on economies and societies, from health and agriculture to consumer goods and energy. These new capabilities and applications are already improving our response to global challenges from climate change to pandemics. More could be found in the MсKensey report by the link

Medical biotechnology is a branch of medicine that uses living cells and cell materials to research and then produce pharmaceutical and diagnosing products. These products help treat and prevent diseases. From the Ebola vaccine to mapping human DNA to agricultural impacts, medical biotechnology is making huge advancements and helping millions of people. Some of the most recent uses of biological tech is work in genetic testing, drug treatments, and artificial tissue growth. With the many advancements in medical biotechnology, there are new concerns that arise. From funding to ethics, there are many things to determine and regulate when it comes to this fast-paced industry. Learn about the many technical biology advancements and the concerns surrounding them. From cancer research to agriculture advancements, medical biotechnology has many promising avenues of technological growth that have the potential to help many people.

Major Medical Biotechnology Advancements are:

1. CRISPR. CRISPR technology or CRISPR-Cas9 utilizes a protein called Cas9, which acts like a pair of molecular scissors and can cut DNA. CRISPRs are specialized stretches of DNA and are used in medical biotechnology as a tool to edit genomes. This allows scientists to alter DNA and modify gene functions, often called genetic engineering. There are many applications, like correcting genetic defects, treating diseases, preventing the spread of diseases, improving crops, and more. But the science of altering genomes has many ethical concerns surrounding it. From the ability to mutate genes and the unknowns surrounding gene mutation, CRISPR is a controversial area of biomedical science. Some new studies even show that perhaps CRISPR technology can create tumors and cancer with DNA deletions that aren’t controlled or precise. Of course, pharmaceutical companies and other scientific organizations that develop and utilize CRISPR technology are trying to downplay the concerns and issues, so the reality of the benefits and damage of the technology is somewhat unknown.
2. Tissue Nanotransfection. New science may have the ability to heal people with a single touch. Sound too good to be true? It’s not. Tissue nanotransfection works by injecting genetic code into skin cells, which turns those skin cells into the other types of cells required for treating diseases. In some lab tests, one touch of TNT completely repaired the injured legs of mice over a period of a few weeks by turning skin cells into vascular cells. And reportedly, this biotech can work on other types of tissue besides skin. The potential for this type of gene therapy is huge, from helping car crash victims to active duty soldiers. Medical biotechnology has made this advancement possible, and continued research and testing will only help improve this tech and adopt it across hospitals and medical centers.
3. Recombinant DNA Technology. Recombinant DNA technology is combining DNA molecules from two different species and then inserting that new DNA into a host organism. That host organism will produce new genetic combinations for medicine, agriculture, and industry. There are many examples of recombinant DNA technology being utilized, from biopharmaceuticals and diagnostics to energy applications like biofuel to agricultural biotechnology with modified fruits and veggies. Genetically modified products are able to perform better than the regular medicine or produce. Recombinant agriculture is able to be more pest-resistant or weather resistant; recombinant medicine like insulin is able to better work with bodies, etc. Because of the many benefits that recombinant DNA holds for a variety of products, researchers are optimistic about the future it has within biosciences and in other industries as well.
4. Genetic Testing. Genetic and ancestry kits are popular these days, and they are beneficial for more than just helping people understand their genetics and heritage. New studies are showing that saliva kits are able to test for things like breast cancer by looking at gene mutations. Certain races are also more likely to inherit certain mutations or human diseases, and knowing what races make up your genetic material can help you be prepared. While 23andMe test results shouldn’t be a reason to make decisions about treatments, understanding your heritage and how that could impact your health is valuable.
5. HPV Vaccine. You’ve probably heard of the Human Papilloma Virus (HPV) and how it’s linked to cervical cancer—which is the second most lethal form of cancer for women, next to breast cancer. Statistics show that cervical cancer kills 275,000 women annually, which is why a vaccine for HPV is so important. The good news is there are now two vaccines on the market—Cervarix and Gardasil—that have been approved by the U.S. Food and Drug Administration for use in women from ages 9 to 26.
6. Stem Cell Research. Biotechnology plays a big part in supporting stem cell research, which supports the exploration of growing stem cells in a lab setting or in vitro. This could help in situations where patients may be suffering from a disease or disorder where implanting stem cells could help restore their vitality and give them a new lease on life. How does it work? Because stem cells can repeatedly divide and transform into other types of body cells, biotechnologists can learn how to work with their unique profiles to encourage growth of specific types of cells. Though research is ongoing, it’s reported that the results show hope for the future of this unique medical approach.

Like many other advances in life science and medicine, CRISPR was inspired by nature. In this case, the idea was borrowed from a simple defense mechanism found in some microbes, such as bacteria. To protect themselves against invaders like viruses, these microbes capture snippets of the intruder’s DNA and store them away as segments called CRISPRs, or clustered regularly interspersed short palindromic repeats. If the same germ tries to attack again, those DNA segments (turned into short pieces of RNA) help an enzyme called Cas find and slice up the invader’s DNA. 

After this defence system was discovered, scientists realized that it had the makings of a versatile gene-editing tool. Within a handful of years, multiple groups had successfully adapted the system to edit virtually any section of DNA, first in the cells of other microbes, and then eventually in human cells. CRISPR allows scientists to cut specific snippets of DNA from a cell's genetic code and paste into new ones if desired. Stadtmauer and his colleagues applied this technique to T cells, a type of white blood cell that attacks diseased and cancerous cells in the body. Cancer uses several tricks to slip under the T-cell radar, but using CRISPR, researchers aim to help the immune cells spot elusive tumors and take them down. 

CRISPR is becoming a mainstream methodology used in many cancer biology studies because of the convenience of the technique. Researchers are exploring different ways to fine-tune the delivery of CRISPR to specific organs or cells in the human body. Some are testing viruses that infect only one organ, like the liver or brain. Others have created tiny structures called nanocapsules that are designed to deliver CRISPR components to specific cells. More information on this matter can be found by the link

Researchers from Harvard University looked at factors that might increase the chances of a longer life. Using data collected from men and women from the Nurses’ Health Study and Health Professionals Follow-up Study who were followed for up to 34 years, researchers identified five low-risk lifestyle factors: healthy diet, regular exercise (at least 30 minutes daily of moderate to vigorous activity), healthy weight (as defined by a body mass index of 18.5-24.9), no smoking, and moderate alcohol intake (up to 1 drink daily for women, and up to 2 daily for men). Compared with those who did not incorporate any of these lifestyle factors, those with all five factors lived up to 14 years longer.

In a follow-up study, the researchers found that those factors might contribute to not just a longer but also a healthier life. They saw that women at age 50 who practiced four or five of the healthy habits listed above lived about 34 more years free of diabetes, cardiovascular diseases, and cancer, compared with 24 more disease-free years in women who practiced none of these healthy habits. Men practicing four or five healthy habits at age 50 lived about 31 years free of chronic disease, compared with 24 years among men who practiced none. Men who were current heavy smokers, and men and women with obesity, had the lowest disease-free life expectancy. (source link)

Since the 1980s, when the first “longevity” gene was mapped by scientist Tom Johnson, there’s been more progress made in understanding how we age and how we can slow it down. Moreover, the similarity between aging and age-related diseases is increasingly becoming the focus for many of these longevity research initiatives — many researchers studying age-related diseases like Alzheimer’s are now collaborating with researchers looking at aging more broadly. Biogerontology is the scientific discipline dedicated to the biology of aging. Recent studies have identified key traits — referred to as hallmarks of aging — that attempt to define what aging is. Longevity research on its own has seen a lot of progress, especially as we learn more about the biological processes that underlie aging. But it’s also become more intertwined with research studies focused on major diseases due to similar traits at the cellular and molecular level. For example, there’s a higher probability of lethal gene mutations as one ages that can result in diseases such as cancer or Alzheimer’s. This is a big reason why many drug companies are targeting aging in an attempt to stave off other degenerative diseases.

Cancer begins when abnormal cells start dividing and growing at an uncontrollable rate. This can happen when the body’s proper safeguards or checkpoints go awry, especially with older age. These malignant cells continue to replicate until they’ve invaded other tissues, organs, or body systems. Oftentimes, the extent of their growth is only realized after a person develops disease symptoms. Because the median age for a cancer diagnosis is 66, understanding cancer’s disease pathology could reveal new insights into what exact mechanisms also affect aging. This is precisely why some drug companies are building out their drug pipelines to include medicines that target both cancer and aging.

The latest scientific researches uncovered 12 key causes of aging that could be complexly targeted for longevity, such as:

1. Mitochondrial Dysfunction. Mitochondria are the powerhouses of our cells. They produce the energy our cells need to stay alive and function properly. Cells contain, on average, hundreds to thousands of mitochondria. The older we get, the more our mitochondria become damaged and dysfunctional. Mitochondria are damaged by various mechanisms during our lifetime, such as mutations in their DNA during division, free radicals, and epigenetic changes. When mitochondria are damaged, cells lack the energy to function properly and sustain themselves. In addition, damaged mitochondria send signals to the cell, further disrupting the normal functioning of the cell. This leads to aging. Various natural substances can improve mitochondrial health, such as malate, alpha-ketoglutarate, glycine, glucosamine, vitamin C, and pterostilbene.
2. Cellular Senescence. As we age, more and more senescent cells appear in our tissues. Senescent cells are cells that have been damaged but do not die. They continue to live and secrete substances that damage surrounding, still healthy cells. Senescent cells disrupt the proper functioning of tissues, especially when they accumulate above a certain threshold, secreting substances that are pro-inflammatory, damage tissues and accelerate aging. Certain substances can destroy aging cells. Such substances are called "senolytics". Examples of natural senolytics are fisetin and quercetin.
3. Loss of Proteostasis. Proteins are the building blocks and workhorses of our cells: they build our cells and carry out most of their functions. Proteins are constantly broken down, recycled and rebuilt - this finely tuned process is called protein homeostasis or "proteostasis". However, this process is not perfect, and over the course of our lives, more and more proteins begin to linger around, begin to accumulate, forming protein heaps or lumps both inside and outside the cells. These protein heaps or clumps eventually become so large that they prevent the cells from functioning properly. Too much protein accumulation can lead to "proteotoxicity" and even cell death. Protein accumulation is one of the reasons why cells become dysfunctional with aging, or, in fact, why they age. Certain natural substances can slow protein accumulation, such as glycine, pterostilbene, lithium, and glucosamine.
4. Altered Cellular Communication. When we get older, increasingly higher levels of deleterious substances can be found in our bloodstream and cellular fluids. Examples of such substances are proinflammatory factors and many other proteins, peptides, metabolites, and hormones that damage our cells and accelerate aging. Probably many of the most damaging circulating substances are the ones that promote a continuous state of low-grade, systemic aging-related state inflammation, also called “inflammaging”. The increase of these inflammatory factors is caused by various mechanisms, including senescent cells, a dysregulated microbiome, a leaky gut, the aging immune system, chronic pathogens like viruses, mitochondrially-derived proinflammatory substances, and so on. Specific natural substances can reduce this pro-aging cellular milieu, for example by reducing inflammaging (low-grade aging-related inflammation).
5. Genomic Instability. As decades pass, our DNA becomes more and more damaged. DNA contains the instructions to build proteins, which carry out most of the functions in our cells. Proteins also build up our cells. The more DNA is damaged, the less cells can carry out their functions properly. Too much DNA damage also activates various responses of the cell, leading to further damage, or to the rise of senescent cells, which are cells with too much DNA damage that secrete harmful substances.
6. Epigenetic Alterations. The epigenome determines which genes are switched on or off. The epigenome enables far more precise regulation of cellular functioning than the genome (our genes or DNA). The older we get, the more the epigenome becomes dysregulated: beneficial genes are turned off that should be turned on, and deleterious genes are turned on that should be switched off. Many other changes happen to the epigenome, undermining the cells’ ability to function properly, contributing to the aging process. Reprogramming the epigenome has shown to extend lifespan in organisms, and can even partially reverse aging. Specific substances can beneficially impact the epigenome, such as glycine, fisetin, alpha-ketoglutarate, vitamin C and lithium.
7. Telomere Shortening. Telomeres are the short caps at the ends of our DNA strands that prevent the DNA from unraveling. You can compare telomeres with the caps at the ends of shoelaces which prevent them from unraveling. With each cell division telomeres become shorter. After many cell divisions, the telomeres have become so short that they cannot protect the DNA anymore, which starts to get damaged. Telomeres not only shorten, but also get more and more damaged during aging, which also leads to cellular stress and DNA instability. Telomere length is not strongly correlated with lifespan. However, the speed at which telomeres shorten is strongly correlated with lifespan. Cancer cells have the ability to continuously lengthen their telomeres, making them “immortal” in the sense they can keep dividing without their telomeres  becoming too short, which would lead to cell death. This led many scientists to believe that lengthening telomeres increases the risk of cancer. However, studies have shown that lengthening telomeres does not contribute to a higher cancer risk. In fact, longer telomeres can protect against cancer, especially given short telomeres are associated with genetic instability, which increases the risk of cancer.
8. Deregulated Nutrient Sensing. During aging, important metabolic pathways become more and more dysregulated. These pathways regulate how our cells respond to nutrition. Examples of these pathways are receptors in the cells that gauge amino acid and carbohydrate levels, or that measure intracellular energy levels. The more these nutrient sensing pathways are activated by nutrients like amino acids or glucose, the faster we age. This is because an overabundance of nutrients shifts cells into the “lazy” modus, so that they repair and mainstem themselves less well, which accelerates aging. On the other hand, a scarcity of nutrients, as happens during fasting or by reducing nutrient intake, puts cells into a maintenance and repair modus, which slows down aging. The western diet with an overabundance of fast sugars, animal proteins and unhealthy fats leads to an overactivation of these nutrient-sensing pathways, and accelerates aging. Specific natural substances can inhibit these nutrient-sensing pathways, enabling the cells to repair, maintain, and protect themselves better.
9. Stem Cell Exhaustion. Stem cells give rise to the cells that build up our tissues. For example, mesenchymal stem cells generate bone cells, fat cells and fibrous tissue cells. Liver stem cells build liver cells. Hematopoietic stem cells produce white blood cells and red blood cells. During aging, stem cells become dysfunctional or die off. This leads to our tissues being less replenished and maintained. Stem cells decline because of epigenetic changes, DNA damage, telomere shortening, protein accumulation, mitochondrial dysfunction and other aging mechanisms. These mechanisms damage and age the stem cells. Specific natural substances can improve stem cell health.
10. Disabled Macroautophagy. Macroautophagy disablement occurs when a body’s cells are unable perform a cellular self-cleaning known as autophagy. This leads to the accumulation of damaged or dysfunctional cellular components and is associated with cancer, metabolic and neurological disorders. Substances that help the body to manage disabled macroautophagy: Lithium, Glucosamine, Fisetin, Pterostilbene, Glycine.
11. Inflammaging. Inflammaging is a chronic, low-grade inflammatory state that occurs as part of aging, and can be influenced by lifestyle factors. It can contribute to age-related diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders. Substances that help the body to manage inflammaging: Glycine, Fisetin, Pterostilbene, Ginger, Lithium, Magnesium, Alpha-ketoglutarate, Rhodiola, NMN.
12. Microbiome Dysbiosis. Dysbiosis is a disruption in the normal microbial community that inhabits an environment, like our guts. It can lead to digestive disorders, immune system dysfunction, and increased risk of infection and chronic disease. Substances that help the body to manage microbiome dysbiosis: Ginger, Pterostilbene, Fisetin, Rhodiola rosea, Lithium.

More specific info could be found by the link

Geriatric doctors, also called geriatricians, specialize in caring for aging adults who often have complex medical issues. They focus particularly on keeping you functional and helping you maintain your quality of life. Geriatric doctors understand caregivers' roles and work with family. Geriatric doctors diagnose and treat issues that affect older adults. Their patients often have one or more chronic health issues. The National Council on Aging reports that 80% of older adults have at least one chronic disease, and 68% have at least two. 

The first step in de-aging (reversing or fight with aging)  involves a complete examination of the body: blood tests for various hormones, ultrasound, calculation of the ratio of adipose and muscle tissue, determination of the number of antioxidants, heavy metals, trace elements in the body, etc. All these parameters are necessary to determine the real biological age, since there are biomarkers in the body that can be used to talk about the degree of wear of a particular organ.

In order to support the body and stay healthy, there is a set of measures such as physical activity, proper nutrition, feeding the body with useful substances (for example, absolutely harmless antioxidants, nootropics to stimulate the brain, various dietary supplements and several pharmaceutical preparations: hormones that “improve sleep”, antidepressants, as well as a drug that is usually prescribed for patients with diabetes). All these measures are purely individual and involve tracking personal biomarkers, because people are different, what is good for one is contraindicated for another. Such a study of the indicators of your body and control over them help to de-age and live longer.

Demographic changes toward the aging population are accompanied by the increasing rate of non-communicable (NCDs) chronic diseases, in which the high demand for continuous patient monitoring, treatment access, prolonged hospitalizations, as well as financial issues represent a global concern affecting the entire healthcare system and management. However, although the onset of symptoms in NDCs might be delayed or reduced, the adoption of preventive measures would be recommended to improve patient health and quality care services. Thus, moving from a reactive (focused on treatment) to a proactive system focused on prevention, the future of healthcare is embraced in the so-called “P4” of medicine: preventive, predictive, proactive, and participatory. Based on this approach, the possibility to predict a disease based on specific biomarkers, personalized treatments, and empowered patients toward their health monitoring while preventing diseases, would become a milestone in the perspective of healthcare innovation.

The main thing in modern preventive medicine is a wide diagnostics, especially genetic. Previously, these tests were more of a pastime, but in recent years they have helped to change the way of life in practice and lead to improvements in health on the way to longevity. In addition to the genetic passport, blood biochemistry, and standard ultrasound and ECG, it is also now possible to take indicators such as peak oxygen consumption (one of the main criteria for the effectiveness of treatment) metabolic rate and analyze the composition of the microbiome. In addition, it is possible to determine the biological age by phenotypic measurement. All this allows to work with the body at the epigenetic level, "turn off" incorrectly working genes with the right methods and stop diseases and age-related changes.

There are seven main areas of "health strategy": research, therapy, nutrition, society, environment, physical activity, mental well-being.
In fact, striving for anti-aging they have to be all treated simultaneously and multi-dimensionally. It is necessary to identify and eliminate functional deficiencies, cure concomitant diseases, carry out hormonal correction, work with the microbiome, and gene expression check - these risk prevention measures provide the ability to secure where there is a breakdown at the genetic level. Having solved all the issues, it is possible to get visible changes: physical and intellectual activity, libido and self-esteem will increase, as well as the condition of the skin and hair will improve.

ILBI (intravenous laser blood irradiation) is a method that is used in preventive medicine to combat various diseases and became widely used in de-aging. Intravenous laser blood irradiation is one of the blood purification methods, which consists in processing the blood with a light wave right inside of the circulatory system without being removed from the patient's body. Light waves are able to act in a complex way, normalizing the work of various systems and metabolic processes of the body. A short wave of red light leads to the shape of erythrocytes, which for various reasons have become body-positive and have lost the ability to squeeze into small capillaries. This method helps to improve the condition of patients with various diseases such as high blood pressure, diabetes and heart problems and also accelerates the healing of scars, relieves inflammation and allows you to breathe deeply.

Biohacking is bad in some way when it is forced because the body gives the owner control over the functions that it performed automatically: digestion of food, synthesis of necessary substances, hormonal regulation. Complete control over the performance of the body and an attempt to give it everything it needs in a ready-made form - dietary supplements and vitamins - failed as an idea. Nature is wiser than man. You don’t need to argue with it as the truth is in the balance. All you have to do is only in some cases “turn on traffic lights” at intersections, leading your body in the right direction and acting delicately in modifying processes in the body, so as not to harm it.

Immunity and physical activity are directly related. Sleep should also be mentioned. The fact is that physical activity forms certain hormonal levels, and hormones are associated with the activation of immune system cells. At the same time, when we sleep, we synthesize the hormone Melatonin, which is a natural immunomodulator. Therefore, the balance of physical activity and rest is important here. At the same time, physical activity should be of medium intensity and adequate for a certain age.

Aging is a biological process, which is accompanied by a gradual disruption of body functions up to their complete loss. At the same time, the risk of developing age-related diseases increases.

Biotech beauty is an encompassing term for the perfect fusion of natural ingredients with lab-made chemicals to conjure synthetic alternatives to the planet’s finite natural resources. Biotechnology is an exciting way to recreate some of the most highly sought after natural ingredients without having a negative impact on the Earth. Biotech beauty products contain ingredients that are enhanced in ways that improve their effectiveness, but the amount of potential irregularities and impurities can be eliminated. Biotech products offer the same great results as 100% naturally obtained ingredients, but have almost zero negative impacts on the environment.

GPO members are the passioned longevitists who buy the products created by spinoff engineers i.e. direct/indirect retailers and private manufaturers in each individual home market. Each GPO member out of 75 countries has a legal entity/ staff / offices / warehouses / training premises/ budget and it is desirable to have at least one and more points of sales or POS (e.g. own clinics, offline and/or online stores, beauty salons and do distribution themselves or network with other local retailers/professional distributors). GPO doesn’t cooperate with entities which act only as distributors or agents and do not sell anything directly to customers and do not have direct access to them, as well as with any other forms of the middleman. Each GPO member is independent of the others and decides on his own whether to work with the brands from the GPO portfolio or not according to his financial sources and capabilities. It is very important that all members of the group have equal rights regardless of any factors. They interact with each other exchanging best practices, new trends, experiences, marketing and sales statistics and feedback on brands in the portfolio. These connections have been accumulated over many years in corporate business and operating in the healthcare and aesthetic medicine industry.

Taking into account the confidentiality and cherish the time of all GPO Members, the detailed information about them is provided to each individual retail brand upon request, according to and only after the direct interest by the partner in this particular brand. If, after acquaintance with the brand, GPO Member is interested in the brand distribution, the centralized Procurement office is ready to provide all the expanded profile on the particular GPO Member to this brand i.e. the company name, contact details, annual sales volumes, brands references, local sales channels with which he works etc.

GPO provides its members:

Turnkey portfolio of unique high-margin brands and its constant updating;

• Access to deeply discounted, pre-negotiated contracts;
• 100% distribution exclusivity for each particular market;
• Diluting risks and marketing expenses between all members;
• Improving a part of the procurement chain;
• Increasing speed to market and speed to profit;
• Benchmarking, audit and analysis of similar activities within the GPO structure to identify errors and to avoid the principle “learning by doing”;
• Multiple compensations in case of the independent brand exit;
• Centralized advanced group training, offline and online seminars, open tables etc.;
• Support with logistics by importing/exporting goods within the EU/CIS/Turkey;
• Just-in-time (JIT) deliveries directly across the EU/CIS/Turkey;
• Opportunity to save money on freezing VAT through own dropshipping possibilities within the EU/CIS/Turkey.

GPO provides suppliers:

• Big volumes of purchase;
• Contract-guaranteed projected demand;
• General conditions and discounts for all GPO members;
• Protection against cross-border selling and clients poaching;
• Reduction of operational costs on the search of potential distributors in each market separately;
• Real customer checks and charge-free market assessment, competitors and pricing evaluation from 75 markets within BRAND LAB;
• Zero time to market;
• Dynamic growth and a rapid increase in cash flow.

Group Procurement Organization consists of and is regulated by its independent members that represent a single buying power. Thus, it is not any kind of agent or consultant, since all members BUY products from biotech brands CASH UP FRONT and SELL in up to 75 markets, respectively risk with own money and reputation the same as the brand owners.

The focus of GPO is on brands utilizing the latest cutting-edge biotechnologies and discoveries that radically enhance human healthspan. 

MUST HAVE FOR BRANDS:

• innovative products developed by spinoffs, skilled former engineers originating from corporate environments;
• a clear product strategy of how the product enhances human healthspan;
• 100% USP applying the latest innovations and scientific technologies;
• proved results based on clinical trials;
• high margin;
• big potential market;
• the brand owner is ready for an aggressive S&M strategy;
• the brand owner doesn’t plan to sell the brand for at least within 24 months.

All GPO brands can be downloaded as Biotech Brands Report in the convenient .pdf  form with just one click.

The brands' portfolio can be also found on the main page.

Since GPO develops private label from A to Z completely at its own expense and independently from the manufacturer, it retains full rights to the trademark, as well as intellectual property rights and remains unbound to the location of the production facilities. In case of such brand exit, the GPO receives an entire 100% compensation, that is distributed among the members who sold the product. If the manufacturer partially obtains certain rights for the private brand, investing in the brand's production, he gets the share in accordance with his participation in the event of the exit. The rest of the shares are divided between GPO members who were involved in its sales, in the percent ratio tied to purchasing volume.

GPO is funded by:

• Annual flat rate by the GPO members (only €499);
• 10% equity belongs to the GPO when it creates its private-label brands in case of urgent need; Sometimes, there are situations that the brands, that GPO worked with, are bought out by MNCs.
• Since MNC has its distribution network it will no longer work with GPO, and at the same time taken along with the brand our customers. Therefore, we lose a fairly large part of the client base, the revenue from them and have to start working with a new brand from scratch. Since GPO members have invested in this brand a large amount of financial and other resources for its development and promotion, it can count on some kind of compensation. In case of loss of distribution rights and customers, the member of GPO receives compensation from the brand in the amount of cashflow with the brand for the last 12 to 24 months. We receive 10% of the total amount of compensation to cover all legal, court and other expenses;
• In particular cases, if the young brand doesn’t have enough money to develop international sales, instead of selling a part of the company or attracting other financial means (e.g. from venture funds), GPO ensures cash up front payment with large leverage of up to 3 months and protects the brand owner against company diluting. In this case, GPO can count on a small share of brand equity upon reaching a certain volume of cash upfront purchases. We call this “Sales for Equity” (this definition was introduced for the first time by the Head of the GPO Dr.Alexander Miller).

We do not offer any services, since we are a group of businesses that BUY products of independent retail and professional brands (not any kind of corporate brands) globally on cash upfront terms and SELL them locally. Of course, upon request, we deal with certification and partially overtake marketing for brand launch that we share with the brand and agree in the distribution contract. If the product requires additional education, we can also make training locally, since GPO has certain competencies and training facilities for its own needs.

All GPO members buy ready-to-market brands at the same purchasing price with cash up front adhering to common distribution terms and sell in their markets. Despite the fact that the volume of purchases and discounts, based on total purchases by all GPO members, are negotiated, the procurement contracts are concluded with each individual member of the group for each separate market. Accordingly, the retailer-distributor pays to the supplier and receives the products directly according to the terms of the contract. Such a contractual division allows simplifying the procurement procedure and proper build financial relationships between the parties.

Brands mandatory conclude a standard double-sided five-year exclusive distribution agreement with each interested member for his core market. Thus, exclusivity is always given to a specific country and is necessarily tied to the volume of purchases by years. The contract has the possibility of prolongation for at least five years, subject to the fulfilment of the agreed annual purchase volumes by retailer-distributor for his market of exclusivity. If the retailer-distributor fulfils the purchase volume plan, specified in the contract, then the exclusivity remains, if not, then the parties are discussing why it is not possible to fulfil it in advance. If there are problems in the market, then the parties are looking for a solution (for example, the Coronavirus or the product cannot be sold offline/online). If the retailer-distributor does not work on the product properly (e.g. does not invest money or resources enough into its local development etc.), then the brand can revoke the exclusivity or even terminate the contract unilaterally, according to the terms of the contract.

The first step is a brand selection according to the main requirements (a clear product strategy of how the product enhances human healthspan; 100% USP applying the latest spun off biotechnologies and discoveries; the brand has a scientific background with clinical trials and a clear vision of how its product or technology improves and positively impacts human healthspan and longevity, high margin, strong marketing, the potential for fast sales, readiness to aggressive marketing). The centralized team searches for new biotech brands in the portfolio, applying online and offline channels (member’s recommendations, mass media, social media, exhibitions, etc.) and selects the best brands according to generally accepted requirements as stated above. The centralized procurement office under the supervision of the Head of GPO and Focus Group makes an inner assessment of the products. GPO tests the products for short, middle and long-term performance within the BRAND LAB by a group of professional medical doctors and technologists, who either own retail companies or work for them and have the necessary experience and competence. Afterwards, if the centralized office selects a brand according to positive test results, it is further presented to all GPO members with the help of a unique dossier that is created by a centralized team based on the brand's information and uploaded to the Spinoff.org Platform.

Since quality and biotech USP is the most important thing to make a decision to move ahead, each brand, that is later selected to the portfolio, goes through the initial Brand Lab. It is the process of products testing by Focus Group which includes the management of the centralized Procurement Department, MD, Technical Director and Technologist. Usually, the brand is asked for several full-sized business samples, more likely bestsellers in minimal quantities, that can give a clear understanding of the product USP and packaging quality, to one of the official addresses. Personal care products are tested for their performance in the first place from short to long term results. For food & beverage, of course, it is also important that they have healthy beneficial properties and, of course, great taste.

We have a very deep approach to brand selection. We work closely with leading skin intellectuals called "Skintellectuals" within Brand Lab. The Skintellectuals we work with, approach ingredients from a scientific point of view and study in detail the composition of products and the technology behind them. They cannot be bribed only with spectacular packaging anymore. They don't just know that cream can oxidize. They can tell you how BHAs differ from AHAs. This is quite often a group of scientists whose mission is to “hack the beauty industry”.

Upon the initial Brand Lab testing results by GPO's centralized Focus Group and, if the brand is interesting and matches all the criteria of brand selection, as well as the price list is pre-evaluated as adequate, the brand is equally presented to all GPO Members. For this reason, a professional publication called Dossier is made in two forms. The Open Dossier at the platform is presented to all partners. The closed so-called Secret Dossier (a more extended version with additional sometimes sensitive infromation) is made for a deeper presentation of the new potential brand to interested partners. Afterwards, open markets and interested partners are checked on compliance, excluding occupied markets or with exclusive distributors at the brand's discretion. After acquaintance with the dossier, prices and presentation based in Secret Dossier, a series of online negotiations and conferences are taking place. In accordance with the interest and feedback, GPO Members request business samples to present a product locally and evaluate the market according to the trading standards. This is when the second stage of Brand Lab begins.

At this stage, the brand's products are provided to GPO Members upon their direct request and in accordance with their interests. The business samples are sent to chosen markets in order to test them locally by the partners and present to points of sale and in the retail chains. This helps to receive direct interest and feedback and plan the total volume of purchases for each local partner at each separate market. Brand Lab from up to 75 markets is made on real customers and provides charge-free market assessment for a given brand, competitors and pricing evaluation, and recommendations from the partners on introducing the brand to each individual market, improving the product packaging, etc. This stage usually lasts up to 3-4 weeks.

Naturally, there is no specific time frame. After the brand was introduced to all GPO members with the professional dossier and the most interested retailers-distributors have received business samples for testing, this process we call BRAND LAB, approximate it can take up to a month under normal market conditions and the world market as a whole and varies for each individual member. GPO members in a specific market need time to test the product internally within the team by professional technologists and doctors (cosmetologists etc. in the case of a beauty product) for the short-term, medium-term and long-term action, to make market estimation and also calculate the margin, logistics and the price for each individual brand. Thus, this process is very crucial but quite time-consuming. Sometimes happens that part of the assessment process is done in parallel between the retailer-distributor and the brand within the framework of the negotiation process, in this case, the feedback from members may be obtained faster. In addition, by having direct brand coordinates, group members can contact it directly, while it is difficult to characterize the specific time frame when this will happen.

After the assessment of the products, the centralized team personally informs GPO members in 75 markets about new potential brand in the portfolio and updates with all news with the help of special personal notifications. Based on the GPO members request and feedbacks, the team arranges online conference calls between the parties. At the final stage, after the presentation and warm introduction by the team, all communication is transferred to GPO member for further direct interaction. Also, in some cases, the team helps with the provision of business samples to GPO members, at their request, as well as with certification, sales and marketing and international go-to-market strategy, customers check and product demand in all markets. Usually, after the preliminary online conferences and meetings between the interested parties, if the situation permits, GPO members hold a personal centralized meeting with RB where it is more convenient for everyone, to define all the conditions and sign BB-GPO member direct contracts. 

First and foremost, marketing and promotion expenses are always the goodwill of both parties and always a subject of negotiations for a procurement contract and included as a separate clause in the contract. The manufacturer usually obliges to supply the retailer-distributor with any available and updated marketing materials in order to adequately represent the brand locally. That is, when it comes to PR and marketing, the parties perfectly understand that it requires adaptation for each market, at least there should be a translation of all materials into local language etc., in this regard, there is always a moment when the parties sit down and discuss all these costs on marketing, PR, samples, training etc. 

These costs for marketing are usually included in the percentage of sales or in the margin. It is also decided with the brand personally, and the company could provide merchandise, marketing and promotional materials as a percentage of each invoice according to the contract. Well, it is always calculated judging by the profit and only by mutual agreement of the parties, that may share funds for marketing, taking into account the sales, discounts, margin, etc.

It is always a transparent and understandable process, based on mutual trust and professionalism since GPO members are always ready to show how much they earn on the brand, as well, based on extensive experience, GPO members know what is the production cost that they buy from the brand. Therefore, it is easy to calculate how much each party invests and determine who and what extent is responsible for these costs. For examples, on the side of retailers-distributors, there is always a valuable customer base, reputation, well build infrastructure and invested sources etc. On a part of the manufacturer, there is an end product, well-structured production processes, proper logistics, delivery etc.

Generally speaking, these costs aimed at marketing and PR are distributed in accordance with the work carried out by one party or another and must be covered by the parties in accordance with implemented activities. 

Here are the main professional deep-tech skincare brands from around the globe that the Spinoff team has been working for years and brought to many markets Biopeptix, Niance, Forlle'd

Dossier presentation serves, first and foremost, to present the brands to all GPO Members and to get feedback from them before starting to work with a particular brand. This detailed information allows GPO members to make their own assessment of biotech brands in the GPO portfolio and also to observe the assessment of others, as well as work with brands directly in the "all in one place" format, or work as a group on solving some problems or within the framework of best practices discussion.

As a standard, for the convenience of GPO members and spinoffs, we developed the Spinoff.org platform that works as a modern assessment tool to secure time and resources. The team compiles dossiers using the information provided by brands, which is shared among GPO members in a convenient electronic form with the well-remembered perpetual link by any modern means of communication. The platform has 10% of visible information, available to all, and 90% of invisible information, secured under the password and available only to GPO members. This detailed information allows GPO members to make own assessment of brands in the GPO portfolio and also to observe the assessment of others, as well as work with spinoffs directly in the "all in one place" format, or work as a group on solving some problems or within the framework of best practices discussion.

The platform has a highly reliable level of protection since all information is located on our own physical secured servers based in Germany. Spinoff.org has its own video streaming. Tailored smart software ensures high-speed uploading/downloading unlimited number documents, including videos, to any device, with any operating system, in the highest resolution without the risk of viruses. It also allows tracking all viewed /downloaded information flow based on IP address, which gives the opportunity to secure all sensitive information.

Spinoff is one of the technology transfer mechanism through which knowledge and/or intellectual property from theoretical and applied science are transferred (spinning off) into physical ready-to-market products, and research results are commercially exploited by industrial application. Once an in-lab application is scientifically feasible it transforms into to-market physical product. Science becomes the starting point for biotech by-products that have spun off their scientific findings for benefit of health span and longevity.

But in our case, we call "Spinoffs" ultra-experienced and highly talented Senior Western Engineers who have previously worked for many years for global corporations accumulating significant knowledge, expertise and connections in their field. At some point driven by an inner desire to apply a revolutionary idea that cannot be implemented within the framework of the multinational corporation for a number of reasons, they decide to spin off and establish their own private businesses to develop and apply new revolutionary solutions (maybe a substitute of the former competitors).

The platform has a highly reliable level of protection since all information is located on secure German servers. Spinoff.org  has its own video streaming. Tailored smart software ensures high-speed uploading/downloading unlimited number of documents, including videos, to any device, with any operating system, in the highest resolution without the risk of viruses. It also allows tracking all viewed /downloaded information flow based on IP address, which gives the opportunity to secure all sensitive information.

In the spirit of science-intensive products, during the company lifespan, our team has managed to cooperate with such large leading medical and biotechnological MNCs as BBraun, Siemens Healthineer, GE Healthcare, Philps Healthcare, AstraZeneca Plc, Bayer AG, Zoetis, Merz Pharma GmbH & Co. KGaA, Novartis AG, Novo Nordisk A/S, Pfizer Inc., Sanofi SA, Takeda Pharmaceutical Co. Ltd,  BASF and a lot of science-based universities/institutions worldwide such as Massachusetts Institute of Technology (MIT) Cambridge, Stanford University, Harvard University. Cambridge, University of Cambridge, University of Oxford, Technion, ETH Zurich, University of California, Berkeley (UCB), Technical University of Munich, Johns Hopkins University and more. Moreover, due to our focus, we work with scientists, MD's, longevitists and geriatric doctors.